API Anti-Inflammatory Naproxen Sodium Powder Material CAS26159-34-2 Naproxen Sodium

• Varieties: Other
• Component: Chemical Synthetic Drugs
• Type: Other
• Pharmacodynamic Influential Factors: Other
• Storage Method: Prevent Exceeding Quality Guarantee Period
• Veterinary Reg. No.: Other
• Model NO.: Naproxen Sodium
• CAS No: 26159-34-2
• Mf: C14h13nao3
• Assay: 100.4%
• Appearance: White Crystalline Powder
• Grade Standard: Medicine Grade
• Shelf Life: 2 Years
• Transport Package: Bag, Carton, Drum
• Specification: 25kg/drum
• Trademark: Arshine
• Origin: China
• HS Code: 2916399090
• Production Capacity: 200 Tons/Year

Product Description

API Anti-Inflammatory Naproxen Sodium Powder Material CAS26159-34-2 Naproxen Sodium   

Naproxen sodium is a kind of non-steroidal anti-inflammatory analgesic that is easier to be tolerated by humans. It belongs to the phenylpropionic acid compound and exerts anti-inflammatory and analgesic effects by inhibiting the synthesis of prostaglandins.
It is clinically suitable for alleviating various mild to moderate pains, such as pain after tooth extraction and other operations, primary dysmenorrhea and headaches. It is also suitable for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, juvenile arthritis (Juvenilearthritis), tendinitis, bursitis and acute gouty arthritis. Limits have the effect of relieving symptoms. Psoriatic arthritis and Reiter's syndrome can also be treated with this product. Compared with ibuprofen, fenoprofen, aspirin, sulindac and indomethacin, the effect of symptom relief is similar.
Efficacy and effect
Naproxen sodium has strong anti-inflammatory and analgesic effects, and its main biological effects are:
(1) Inhibit the activity of prostaglandin synthase, thereby reducing capillary permeability;
(2) Reduce the production of superoxide by macrophages to play an anti-inflammatory effect;
(3) Stimulate T inhibitory cell activity;
(4) Reduce pain sensitivity. Compared with ibuprofen, fenoprofen, aspirin, sulindac and indomethacin, the symptom relief effect is similar, but the incidence and severity of adverse reactions in the gastrointestinal tract and nervous system are lower.

Items	Standard	Test Result
Appearance	White or almost white crystalline powder	White crystalline powder
Identification
A. Infrared absorption	The infrared absorption spectrum is concordant with the reference spectrum	Conform
B. Ultraviolet Absorption	Absorptivities at 272nm, calculated on the dried base, do not differ by more than 3%	1%
Specific rotation	-17.0°~-15.3°	-16.8°
Loss on drying	≤1.0%	0.2%
Heavy metals	≤0.002%	<0.002%
Free Naproxen	≤1.0%	0.1%
Related substances(HPLC)
Impurity D(in-house)	≤0.10%	<0.01%
Impurity E(in-house, impurity C in EP)	≤0.10%	<0.01%
Any other impurity	≤0.10%	<0.01%
Total impurities	≤0.5%	<0.01%
Residual solvents
Toluene	≤50ppm	<1ppm
Methanol	≤50ppm	<4ppm
Assay(on dry basis)	98.5%~101.5%	100.4%
Conclusion	The results conform with USP38.