China Vitamin B12 Hydroxycobalamin HCl CAS 58288-50-9 Hydroxocobalamin Chloride

• Varieties: Other
• Component: Chemical Synthetic Drugs
• Type: Other
• Pharmacodynamic Influential Factors: Other
• Storage Method: Prevent Exceeding Quality Guarantee Period
• Veterinary Reg. No.: Other
• Model NO.: Hydroxocobalamin Chloride 58288-50-9
• CAS No: 58288-50-9
• Mf: C62h90clcon13o15p
• Purity: 99%
• Appearance: Dark Red Fine Powder
• Grade Standard: Medicine Grade
• Shelf Life: 2 Years
• Transport Package: Bag, Carton, Drum
• Specification: 25kg/drum
• Trademark: Arshine
• Origin: China
• Production Capacity: 200 Tons/Year

Product Description

China Vitamin B12 Hydroxycobalamin HCl CAS 58288-50-9 Hydroxocobalamin Chloride

Hydroxocobalamin, also known as hydroxycobalamin, is a member of the class of compounds known as cobalamin derivatives. These organic compounds contain a corrin ring, a cobaltatom, and a nucleotide moiety. Cobalamin derivatives are actually derived from vitamin B12. Hydroxocobalamin is practically insoluble (in water) and a moderately acidic compound (based on its pKa). Hydroxocobalamin is formally rated as a possibly carcinogenic (IARC 2B) potentially toxic compound. Hydroxocobalamin is a drug used in the treatment of pernicious anemia and in the prevention and treatment of vitamin B12 deficiency arising from alcoholism, malabsorption, tapeworm infestation, celiac disease, hyperthyroidism, hepatic-biliary tract disease, persistent diarrhea, ileal resection, pancreatic cancer, renal disease, prolonged stress, vegan diets, macrobiotic diets, and other restrictive diets. Hydroxocobalamin is also used in the treatment of known or suspected cyanide poisoning.
Use
1) Hydroxocobalamin is commonly used to address vitamin B-12 deficiency.
2) Hydroxocobalamin received approval for use as a treatment for cyanide poisoning. 
3) Hydroxocobalamin has been identified as a scavenger of nitric oxide, an essential muscle regulator that also acts as a free radical.

Item	Specification	Test Results	Testing methods
Appearance	Dark red, crystals or crystalline powder	Complies	Monograph:0547 Visual method
Identifiction A	UV:Absorption maxima at 274±1nm,351±1nm and 525±2nm.274±1nm,351±1nm,525±2nm	Complies	Ph.Eur.monograph Ph.Eur. <2.2.25>
	A274nm/A351nm: 0.75~0.83 A525nm/A351nm: 0.31~0.35	0.79 0.33
Identifiction B	TLC:The principal spot in the chromatogram obtained with the test solution is similar in position,colour and size to the principal spot in the chromatogram obtained with the reference solution	Complies	Ph.Eur.monograph Ph.Eur. <2.2.27>
Identifiction C	Chlorides:It gives reaction(a) of chlorides	Complies	Ph.Eur.monograph<2.3.1>Chlorides
Loss on drying	8.0%~12.0%	8.4%	Ph.Eur.monograph Ph.Eur<2.2.32>
Assay	96.0%~102.0%	98.8%	Ph.Eur.monograph Ph.Eur<2.2.25>
Related substances	≤5%	2%	Ph.Eur.monograph/ Ph.Eur<2.2.29>(HPLC)
Acetone	≤5000ppm	22ppm	In house/(GC) (GC)SOP-QC-158-04-03
Total aerobic microbial count	≤1000cfu/g	<10cfu/g	ChP 2015<1105>
The total combined yeasts/mould count	≤100cfu/g	<10cfu/g