| Varieties: | Other |
|---|---|
| Component: | Chemical Synthetic Drugs |
| Type: | Other |
| Pharmacodynamic Influential Factors: | Other |
| Storage Method: | Prevent Exceeding Quality Guarantee Period |
| Veterinary Reg. No.: | Other |
| Customization: |
|---|
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Product Name: L-5-MTHF-Ca
CAS NO.: 151533-22-1
Molecular formula: C20H23CaN7O6
Molecular weight: 497.5179
OtherName:CALCIUML-5-METHYLTETRAHYDROFOLATE; (6S)-N-[4-(2-Amino-1,4,5,6,7,8,-hexahydro-5-methyl-4-oxo-6-pteridinylmethylamino)benzoyl]-L-glutaminsure, Calciumsalz (1:1); L-5-Methyltetrahydrofolic acid, calcium salt.
Product Description:
L-5-MTHF-Ca (5-mthf) is a naturally occurring salt-forming methyl derivative of folic acid. 5-mthf is also known as levomethyl-folate, which is the most biologically active and functional of folic acid. Form, more easily absorbed than ordinary folic acid. Common folic acid must be converted to type 1 methyl folate to participate in two major metabolic pathways: methylation and DNA synthesis, the only form of free folate normally present in human plasma and cells is 5-mthf. Lack of folic acid is usually caused by vitamin deficiency, which is insufficient for absorption. During pregnancy and breastfeeding, the need for folic acid is increased during the growth of children.
Application Area:
1. Mainly for folic acid antagonists (such as methotrexate, pyrimethamine, benzyl cefalexin and trimethoprim) antidote, it's usually used for prevention of methotrexate dose or overdose treatment caused severe toxic effects.
2. Folic acid treatment of the following diseases, such as inflammatory diarrhea and protein-energy malnutrition (poor nutrition), pregnancy or infancy megaloblastic anemia caused by poor.
3. as adjuvant therapy for colon cancer, rectal cancer
4. Combined with 5-FU and treatment of digestive tract tumors or other 5-FU-sensitive tumors. High-dose CF used in conjunction with 5-FU (LF), the basic programme is currently the treatment of colon and rectal cancer.
5. For children with leukemia, lymphoma, and osteosarcoma, such as high dose MTX treatment when rescued.
| Item | Standard |
| Appearance | White to yellow or beige powder |
| Assay(On dry basis as Ca salt) | 97.0%-102.0% |
| Specific Rotation(C=1.5%in water,25ºC) | +14.5~+18.50 |
| Calcium(Anhydrous basis) | 7.0%-8.5% |
| D-Methylfolate | ≤1.0% |
| Chloride | ≤0.5% |
| Water (K-F) | ≤16.0% |
| Single impurity | ≤1.0% |
| Residual solvent(Ethanol) | ≤5000ppm |
| Chloride(Cl) | ≤0.5% |
| As | ≤1ppm |
| Heavy Metals | ≤20ppm |
| Total plate count | ≤100cuf/g |
| Mold & Yeasts | ≤100cuf/g |
| Salmonella | Negative |
| E. Coil | Negative |
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