Pharmaceutical Intermediate Ceftazidime Pentahydrate+Sodium Carbonate

• Varieties: Other
• Component: Chemical Synthetic Drugs
• Type: Other
• Pharmacodynamic Influential Factors: Other
• Storage Method: Prevent Exceeding Quality Guarantee Period
• Veterinary Reg. No.: Other
• Model NO.: Ceftazidime Pentahydrate+Sodium Carbonate
• CAS No: 78439-06-2
• Mf: C19h18n5nao7s3
• Appearance: White Crystal Powder
• Grade Standard: Medicine Grade
• Shelf Life: 2 Years
• Transport Package: Bag, Carton, Drum
• Specification: 25kg/drum
• Trademark: Arshine
• Origin: China
• Production Capacity: 200 Tons/Year

Product Description

pharmaceutical intermediate Ceftazidime Pentahydrate+Sodium Carbonate

 Ceftiofur sodium is the sodium salt of ceftiofur, which belongs to the third generation cephalosporin antibiotics, Chemical properties are stabie, appearance is light yellow to white crystalline powder, aqueous solution has a shorter retention time, it should be diluted into a solution before use.It is used for the treatment of respiratory disease of sheep,horses, cattle, pigs (pleuropneumonia),and the treatment of pets, day-old broiler infectious diseases.
Function
 Ceftiofur sodium is mainly used for serious infection of bacteria and Escherichia coli and Salmonella in poultry.
1. High temperature and high fever caused by systemic or local infection of viruses and bacteria, coughing, gasping, difficulty in breathing, redness and purpleness of the skin, purple hair in the ears, ulceration of the mouth and hoof, abortion of abortion, circling, hind limb paralysis, no food, no lying Start, constipation and diarrhea.
2, infectious pleurisy, actinomycetes, Pasteurella multocida, Streptococcus mutans, piglet yellow and white peony, Salmonella, Haemophilus parasuis, atrophic rhinitis, chlamydia and so on.
3, livestock prenatal and postpartum high fever, endometritis, mastitis, no milk and less milk syndrome, laminitis, rot rot, bovine bacillus, transport fever, pneumonia, nasal atrophy, etc.
Application 
Ceftiofur sodium is a veterinary clinical special antibiotic for cephalosporins and is a broad-spectrum antibacterial. It has strong antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Ceftiofur acts on the transcriptional peptidase to block the synthesis of the peptide, and the bacterial cell wall is deleted to achieve bactericidal action. Ceftiofur has a stable β-lactam ring and is not easily destroyed by drug-resistant bacteria. It can act on Gram-positive and Gram-negative bacteria producing β-lactamase.
Ceftiofur sodium is a compound preparation for bactericidal, anti-inflammatory, antipyretic and analgesic. Ceftiofur sodium is a third-generation cephalosporin antibiotic for veterinary clinics. It has a broad-spectrum and high-efficiency bactericidal effect. For G+ and G-bacteria, including β- The strains of lactamy mildew have a strong killing effect, and ceftiofur sodium absorbs rapidly after muscle and subcutaneous injection, reaching an effective peak concentration of 0.5-0.3 hours. It is widely distributed throughout the body and is the best new drug for clinical treatment of bacterial diseases.

TEST	SPECIFICATION		RESULT
Character	White or grayish yellow powder,odor free and humidifying		Conform
Identification	1. In the chromatogram of the assay, the retention time of the principal peak in the chromatogram obtained with the test solution corresponds to that of the principal peak in the chromatogram obtained with reference solution 2. It gives flame reaction of sodium salt		Conform
Water	Not more than 3.0%		0.71%
Acidity(pH)	5.5~7.5		6.2
Color of solution	No more intensity colored than reference solution Yedllow 9 or Orange-yellow 9		Less intensely colored than reference solution Yellow 8
Clarity of solution	No more pronounced than that of reference suspension I		Less pronounced than that of reference suspension I
Assay (Ceftiofur sodium)	No less than 98.0%(anhydrous and acetoe free)		98.8%
Related substances	Biggest individual impurity	No more than 0.5%	0.1%
	Total	No more than 3.0%	0.98%
Residual solvents	Acetoe: no more than 2.0%		1.0%
Particulate matter	≥10μm:no more than 5000 particles/g		597 particles/g
	≥25μm:no more than 500 particles/g		27 particles/g
Bacterial endotoxin	No more than 0.2EU/mg (Ceftiofur)		Less than 0.20EU/mg(Ceftiofur)
Sterility	No growth of micro-organisms should occur after 14 days of incubation		No growth of micro-organisms should occur after 14 days of incubation