Pharmaceutical Raw Materials Bmn 673 CAS 1207456-01-6 Talazoparib

• CAS Number: 1207456-01-6
• Common Name: Bmn 673
• Appearance: White Crystal Powder
• Assay: 99.3%
• Melting Point: 247.5~248.5ºC
• Loss on Drying: 0.2%
• Model NO.: Talazoparib
• Residue on Ignition: 0.03%
• Purity (HPLC): 99.3%
• Transport Package: Bag or Drum
• Specification: 1kg/drum
• Trademark: Arshine
• Origin: China
• HS Code: 2933290090
• Production Capacity: 200 Kg/Year

Product Description

pharmaceutical raw materials BMN 673 CAS 1207456-01-6 Talazoparib

 

Talazoparib (BMN 673) is a novel PARP inhibitor with IC50 of 0.58 nM in a cell-free assay. It is also a potent inhibitor of PARP-2, but does not inhibit PARG and is highly sensitive to PTEN mutation. Phase 3.

 

Talazoparib was approved by the FDA for use in germline BRCA mutated, HER2 negative, locally advanced or metastatic breast cancer on October 16, 2018 under the trade name Talzenna. Talzenna was granted approval based on the results of the EMBRACA trial in which talazoparib resulted in a mean 8.6 months progression-free survival time versus physician's choice chemotherapy which resulted in 5.6 months progression-free survival.|Talazoparib is a Poly(ADP-Ribose) Polymerase Inhibitor. The mechanism of action of talazoparib is as a Poly(ADP-Ribose) Polymerase Inhibitor.|Talazoparib is an orally available small molecule inhibitor of the DNA repair enzyme poly ADP-ribose polymerase (PARP) which is used as an antineoplastic agent in the treatment of selected cases of breast cancer. Talazoparib is associated with a moderate rate of serum aminotransferase elevations during therapy and is suspected to cause rare instances of clinically apparent acute liver injury.|Talazoparib is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Talazoparib selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks.

 

Product Name	Talazoparib		Batch number	230901
CAS Number	1207456-01-6		Batch weight	210g
Molecular Formula	C1 9H 14F2N6O		Mfg date	Sep,22,2023
Molecular Weight	380.36		Retest date	Sep,21,2025
TEST ITEMS		SPECIFICATION			RESULT
Descrption		White to off-white crystal powder			white crystal powder
Identification		BY HPLC			Complies
Melting point		247~249ºC			247.5~248.5ºC
Loss on drying		N.M.T 0.5%			0.2%
Residue on ignition		N.M.T 0.1%			0.03%
Purity (HPLC)		N.L.T 98.0%			99.3%
CONCLUSION		The product complies with the requirements of enterprise standard